Re-EMBARC Study

About The Study

The Re-EMBARC study (Establishing Multimodal Brain Biomarkers Using Data-driven Analytics for Treatment Selection in Depression) is a research initiative at the University of Texas at Austin. Researchers are working to identify brain patterns that can predict how individuals with Major Depressive Disorder respond to the antidepressant sertraline (Zoloft).

Quick Facts

Austin, TX

Located at the Health Discovery Building (Dell Med)

Study Medication

Includes treatment with sertraline (Zoloft)

Brain Imaging

Involves fMRI and EEG scans to measure brain function

11 Visits

Includes weekly or bi-weekly clinical assessments

Who Can Participate?

Are an adult with Major Depressive Disorder.
Had your first episode of depression before age 30 (Early Onset).
Have depression that is either Chronic (current episode > 2 years) or Recurrent (2+ lifetime episodes).
Have a Body Mass Index (BMI) under 34
Are not currently in regular depression-specific therapy.
Have not failed a course of antidepressant treatment during your current episode.
Are willing to take sertraline (Zoloft) as part of the study.
Have no history of psychosis, bipolar disorder, or seizure disorders.

What To Expect:

Online questionnaires regarding mood and history

One 2-hour MRI session (3T Siemens Vida scanner)

One 1.5-hour EEG session with cognitive tasks

Evaluation by a board-certified psychiatrist

Treatment with sertraline (Zoloft) for the study duration

FAQ

We’ve pulled together some basics to help you

What medication is used in this study?

The study uses sertraline (brand name Zoloft), a common SSRI antidepressant approved for treating depression.

Why is there a BMI limit?

The MRI scanner has specific space and weight limitations for safety and image quality. Participants must have a BMI under 34 to fit comfortably and safely.

Is there an age requirement?

While you must be an adult to participate, a key requirement is that your depression symptoms first started before age 30.

Where does the study take place?

Visits are held at the Health Discovery Building (HDB) on the Dell Medical School campus in Austin, TX.

Join a Research Study for Adults with Early-Onset Depression